17/04/25 19:21:00.87 CaFrhP+s.net
これは勉強になった。
diverting ileostomｙは皮膚はただれやすいし、脱水に傾くから自分ではcolonostomyを選択していたのだが
分子レベルでの根拠を与えてくれる。
Short-chain fatty acids (SCFAs), such as acetate, propionate, and especially butyrate, produced
by anaerobic metabolism of dietary carbohydrates by commensal bacteria are
an essential source of energy for colonic enterocytes through their entry as
substrates into the tricarboxylic acid (TCA) cycle. Surgical procedures, such
as ileostomy, that remove the normal fecal flow to the colon can cause a syndrome
called diversion colitis, in which enterocytes starved of SCFAs undergo
inflammation and necrosis. Providing SCFAs to the affected colon segment
can reverse this condition.