14/07/13 13:51:56.28
nature誌のletter論文撤回理由(5)
URLﾘﾝｸ(www.nature.com)
>(5) In the Article, one group of STAP stem cells (STAP-SCs)
>was reported as being derived from STAP cells induced from
>spleens of F1 hybrids from the cross of mouse lines carrying
>identical cag-gfp insertions in chromosome 18 in the background
>of 129/Sv and B6, respectively, and that they were maintained
>in the Wakayama laboratory. However, further analysis of the
>eight STAP-SC lines indicates that, while sharing the same
>129×B6 F1 genetic background, they have a different GFP
>insertion site. Furthermore, while the mice used for STAP cell
>induction are homozygous for the GFP transgene, the STAP-SCs
>are heterozygous. The GFP transgene insertion site matches
>that of the mice and ES cells kept in the Wakayama laboratory.
>Thus, there are inexplicable discrepancies in genetic
>background and transgene insertion sites between the donor mice
>and the reported STAP-SCs.