13/08/12 20:30:16.67 +NtOWUha0
Clinical and Pathologic Features of “Sporadic” Papillary Thyroid Carcinoma Registered in the Years 2005 to 2008 in Children and Adolescents of Belarus
URLﾘﾝｸ(online.liebertpub.com)
Results: The incidence rate of PTC was 1.13 per 100,000 persons.
The median age at diagnosis was 15.1 years with fourfold predominance of diagnosis in female patients.
Relapse was detected in 2% of cases with median follow-up of 4.2 years.
Median tumor size was 12 mm. Three percent of the cases of PTC had multifocal growth.
The classical variant of PTC was registered in 46% of the patients with thyroid cancer,
the follicular variant of PTC was noted in 20% of the cases.
The percent of rare types of PTC (tall cell and diffuse sclerosing) were equal to that for solid PTCs (13%, 12%, and 10%, respectively).
Adolescents had a pure papillary carcinoma more often compared to children who represented tumors with mixed papillary/follicular patterns more frequently (p<0.05).
Two-thirds of the patients with PTC had regional lymph node metastases.
ETE was established in 39 of 74 patients in whom ETE could be assessed by morphology.
Multivariate analysis showed that lymphatic invasion was the strongest independent factor associated with both ETE (p<0.0001) and lymph node metastases (p<0.0001).
Conclusion:
In 2005–2008, sporadic thyroid cancer in children of Belarus was represented by high prevalence of PTC and absence of follicular thyroid cancer.
Sporadic cases of PTC in Belarus were characterized by smaller tumor size, a small number of cases with multifocal growth, an equal number of rare types and solid PTCs, a relatively high prevalence of pure papillary variant of PTC in adolescents,
and a low frequency of early relapses.
A high frequency of ETE and lymph node metastases was detected.
The strongest morphologic factor associated with both of them was lymphatic invasion.
＊千葉ウイグルさん
abstractしか見ていません。sporadicの方の平均年齢と、平均腫瘍サイズが載っているようです