12/02/14 05:03:07.42
>>349
直リン化すると、こうかな？
> 349 名前：名無しゲノムのクローンさん 本日のレス 投稿日：2012/02/14(火) 02:08:42.17
> マテメソに対する批判コメントが寄せられています。ご討議ください。
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1.Comment
Anonymous Feb 13, 2012 09:03 AM
About this paper, the material & method section is terrible.
1) murine ZFP709 does not seems to be the genuine orthologue of human ZNF14.
They called human zinc finger protein (ZNF14 NM_021030) as GIOT-4. Furthermore,
they call murine zinc finger protein 709 (Zfp709, NM_145624) as mouse GIOT-4,
which is understood that they assume Zfp709 as murine orthologue of human ZNF14.
In fact, when you search the human homologues of murine Zfp709 with BLASTP,
you can find tremendous amount of homologues of such a gene. Among them,
human zinc finger protein 709 (ZNF709, NM_152601) hits with the most significant similarity,
as the name suggests, which is supposed to be the orthologue of murine Zfp709
without persuasive reason. In turn, when you BLASTP the Mus musculus genome
with human ZNF14, ZFP709 hits with less significance than other genes.
(In my opinion, human ZNF14, human ZNF709 and murine Zfp709 seem
to evolve independently, as the synteny suggests, that is, neighbouring genes are distinct.)
If Zfp709 is not the orthologue of ZNF14, it seems difficult to understand
why they could obtain such results in the paper.