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今年出たばかりのペーパー
Systemic cytokine response profiles associated with respiratory virus-induced
acute otitis media.
Patel JA, Nair S, Grady J, Revai K, Victor S, Brasier AR, Chonmaitree T.
Pediatr Infect Dis J. 2009 May;28(5):407-11.
Department of Pediatrics, University of Texas Medical Branch, Galveston, TX
77555-0371, USA.
URLﾘﾝｸ(www.ncbi.nlm.nih.gov)
BACKGROUND:
Acute otitis media (AOM) results from a complex interplay between the
infectious agents and host immune responses. Cytokines play a major role in the
pathogenesis of AOM, but there are few studies on the systemic cytokine response
during AOM.
METHODS:
Sera were collected from 145 children (median age = 13.5
months) at the time of diagnosis of AOM. Concentrations of 17 cytokines
(IL-1beta, -2, -4, -5, -6, -7, -8, -10, -12, -13, -17, granulocyte-colony
stimulating factor (G-CSF), granulocyte-monocyte-colony stimulating factor,
interferon-gamma, MCP-1, MIP-1beta, TNF-alpha) were determined and correlated
with viral etiology and clinical outcome. The statistical analysis was conducted
using bioinformatics software.