09/07/09 22:31:11 8VZ1U4TR0
こんなレビューを紹介しておくね。
長文英語だから読むの大変だけど、全文ダウンロードできる。
Importance of Respiratory Viruses in Acute Otitis Media
Terho Heikkinen1* and Tasnee Chonmaitree2*
Clin Microbiol Rev. 2003 April; 16(2): 230--241.
Copyright (c) 2003, American Society for Microbiology
URLﾘﾝｸ(www.pubmedcentral.nih.gov)
特にこの中で、次のような一文が出てくる。
Effect of Viruses on the Outcome of AOM
One of the major issues suggesting an active role for viruses in otitis media is that despite the use
of wide-spectrum antibiotics that are effective against the causative bacteria, the clinical response to
antibiotic treatment is often poor. This usually results in the change of the antibiotic and even the
use of several courses of different antibiotics with the assumption that the poor response was due to
bacterial resistance to the antibiotic used. Studies of children with persistent symptoms of AOM
have shown, however, that resistant bacteria only account for approximately 20% of these cases
(105, 123). It is logical to think that if the middle ear mucosa is infected with both bacteria and
viruses simultaneously, eradication of the bacteria with antibiotics may not be sufficient to stop the
inflammatory cascades in the middle ear, and the continuing viral infection may lead to more
prolonged disease.