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Characterization of an Injury Induced Population of Muscle-Derived Stem Cell-Like Cells
Kinga Vojnits, HaiYing Pan, Xiaodong Mu & Yong Li
Scientific Reports volume 5, Article number: 17355 (2015) | Download Citation
We recently discovered a novel population of stem cells from the injured murine skeletal muscle.
These injury induced muscle-derived stem cell-like cells (iMuSCs) are partially reprogrammed
from differentiated myogenic cells and display a pluripotent-like state. The iMuSCs exhibit
stem cell properties including the ability to differentiate into multiple lineages,
such as neurogenic and myogenic differentiations; they also display a superior migration
capacity that demonstrating a strong ability of muscle engraftment in vivo.
IMuSCs express several pluripotent and myogenic stem cell markers; have the capability
to form embryoid bodies and teratomas, and can differentiate into all three germ layers.
Moreover, blastocyst microinjection showed that the iMuSCs contributed
to chimeric embryos but could not complete germline transmission. Our results indicate
that the iMuSCs are in a partially reprogrammed state of pluripotency,
which are generated by the microenvironment of injured skeletal muscle.
URLﾘﾝｸ(www.nature.com)