23/11/10 11:51:08.63 JYur4Msl0.net
>>414
ゲンダイさん、、、、、、
もう東スポさんと同じジャンルなんですね、
貴社の記事は今後すべてギャグとして拝見します、、、、、
貴社が載せる保阪先生も金子先生もギャグ小説ですしね、、、、
医学的にとっくの昔に議論されてまして、
打てばIG4がどんどん増える→免疫不全
なんですよねえ
こういうのは1ミリもご存じない恥ずかしい低学力低知能の媒体、な訳ないですよね？
すべてギャグとして日本人を笑わせるためですよね、ゲンダイさん？
Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination
PASCAL IRRGANG JULIANE GERLING
SCIENCE IMMUNOLOGY
22 Dec 2022
we report that several months after the second vaccination, SARS-CoV-2–specific antibodies were increasingly composed of noninflammatory IgG4, which were further boosted by a third mRNA vaccination and/or SARS-CoV-2 variant breakthrough infections.
IgG4 antibodies among all spike-specific IgG antibodies rose, on average, from 0.04% shortly after the second vaccination to 19.27% late after the third vaccination.
This induction of IgG4 antibodies was not observed after homologous or heterologous SARS-CoV-2 vaccination with adenoviral vectors.
Single-cell sequencing and flow cytometry revealed substantial frequencies of IgG4-switched B cells within the spike-binding memory B cell population [median of 14.4%; interquartile range (IQR) of 6.7 to 18.1%] compared with the overall memory B cell repertoire (median of 1.3%; IQR of 0.9 to 2.2%) after three immunizations.
This class switch was associated with a reduced capacity of the spike-specific antibodies to mediate antibody-dependent cellular phagocytosis and complement deposition.
Because Fc-mediated effector functions are critical for antiviral immunity, these findings may have consequences for the choice and timing of vaccination regimens using mRNA vaccines, including future booster immunizations against SARS-CoV-2.