23/04/02 08:50:17.76 iPrvsLBQ0.net
今回のｍRNAワクチンに使われてる脂質ナノ粒子（Lipid Nano Particle）
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413 自分：名無しのアビガン(東京都) (ﾜｯﾁｮｲ ee7d-wWxq)[] 投稿日：2023/02/26(日) 09:48:20.61 ID:NYGyAM9L0 [1/2]
これは重要だから再度貼っておこう
脂質ナノ粒子（Lipid Nano Particle)に包み込んで細胞に送り込む方法を最初に考えたのが
コロナ当初に逮捕されたバイオナノテクノロジー専門家のハーバード大のチャールズ・リーバー氏
彼は2011年の時点で既にナノサイズのトランジスターを細胞内に送り込むためにLNPを使っていた
2011年のハーバードマガジンの記事
Virus-Sized Transistors
Hyman professor of chemistry Charles Lieber has created a transistor so small it can be used to
penetrate cell membranes and probe their interiors, without disrupting function. The transistor (yellow)
sits near the bend in a hairpin-shaped, lipid-coated silicon nanowire.
↓特にここ
When he finally engineered the tiny device and tried to insert it into a cell, however, he had no luck:
pressing hard enough to disrupt the cell membrane, he reports, killed the cell “pretty quickly.” B
ut when his team coated the hairpin nanowire with a fatty lipid layer (the same substance cell
membranes are made of), the device was easily pulled into the cell via membrane fusion, a process
related to the one cells use to engulf viruses and bacteria. This innovation is important, Lieber explains,
because it indicates that when a man-made structure is as small as a virus or bacteria, it can behave
the way biological structures do.
https:
//www.harvardmagazine.c
om/2011/01/virus-sized-transistors